TypeScript, a higher level version of something that is super high level in the first place. So it's converting from one scripting language to another, not straight down to byte code. So you are developing a sitcom for the Northern American market, but decide to write it in Mexican Spanish, to be translated to American English. Great! It has the same issues as ORMs. Javascript isn't that hard. As for ORMs - How many database changes are you planing on doing? ORMs seam nice for simple stuff, but still ended up slowing stuff down just on the simple stuff (See translating to Mexican Spanish to American English). Start doing complex stuff like joins and join with extra information, then it's just that much overhead.
If you can't do JavaScript, find someone that can. Can't do query in which ever database, find someone skilled in said database. Can't do CSS... Can't do HTML, GTFO of the business.
TypeScript isn't higher level than JavaScript. It is JavaScript, just with a lightweight type system. It doesn't make things "easier" than JS, it makes the process of building large JS apps less error-prone.
If you can't do JavaScript, find someone that can. Can't do query in which ever database, find someone skilled in said database. Can't do CSS... Can't do HTML, GTFO of the business.