I can't speak for the parent poster, but I deployed bottle with the grandparent poster without any significant performance issues*. This was first under mod_wsgi, then paste.deploy once mod_wsgi got to be a headache, and now I'm looking at gunicorn as a simpler alternative to paste.deploy.

So, why the asterisk next to "no issues"? I was able to wedge our app once by doing frequent, unbuffered, blocking socket.reads for one byte at a time in our RPC library... the GIL is a fearsome thing and it didn't play well with this strategy under highly concurrent request loads. I don't see that as a bottle problem, though.

If you're anticipating high loads, though, I wholly recommend looking at Brubeck (http://brubeck.io/) or Tornado (http://www.tornadoweb.org/)