Look for `macos-option-as-alt`. The Ghostty docs use the term "Alt" here to mean using the key as a terminal input modifier rather than for macOS text input. This setting allows you to specify only one option key to use this behavior for.
Was just looking for how to configure this globally. You can create a keybind for every key[0][1] but that's a bit silly faff nonsense in current year 2024.