Yes, I just gave it a quick shot in Chrome. Make sure to wrap your object tag in a div and target that div with oriDomi. Also, be sure to give the wrapper element the width and height of the swf.
I can't vouch for how robust this is -- especially for interactions -- but it seems to work at least superficially.
I can't vouch for how robust this is -- especially for interactions -- but it seems to work at least superficially.