Some proponents of alternative medicine have claimed that coffee enemas have an anti-cancer effect by "detoxifying" metabolic products of tumors.[4] There is no medical scientific evidence to support any anti-cancer effect of coffee enemas.[2][5][6]
Coffee enemas can cause numerous side effects, including infections, sepsis (including campylobacter sepsis), severe electrolyte imbalance, colitis, polymicrobial enteric septicemia, proctocolitis, salmonella, brain abscess, and heart failure.[4][6][7][8][9][10][11][12][13] If the coffee is inserted too quickly or is too hot, it could cause internal burning[14] or rectal perforation.[15] Long term use of coffee enemas can lead to malabsorption of fat, fat-soluble vitamins, and calcium.
The use of coffee enemas has led to several deaths as a result of severe electrolyte imbalance, hyponatremia, dehydration, pleural and pericardial effusions.[8][16] The U.S. Food and Drug Administration (FDA) has ruled that study participants must be warned of the risk of death from coffee enemas in studies that use them.[17][18]
>In a tiny blind self trial I could easily tell this from placebo
>I've forgotten what doses I tried.
>Long lasting panic attack
>Most vile substance I have tasted
This guy wins though:
>1.5 tsp brewed grounds, rectally [caffeine]